Syntheses and Insecticidal Activities of Novel2,5-Disubstituted-1,3,4-oxadiazoles

Abstract

A series of novel symmetrical and asymmetrical 2,5-disubstituted-1,3,4-oxadiazoles and their intermediates were synthesized. A convenient procedure for preparation of aromatic nitrile and ester intermediates is reported. The insecticidal activities of oxadiazoles against Dropsophila melanogaster were recorded, and analysis of structure–activity relationships showed that the highest occupied molecular orbital energy (EH) was the main factor to affect the bioactivities.