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Stereoselective Synthesis of Trisubstituted Tetrahydropyrans from Baylis-Hillman Derivatives via <i>n</i>-Bu<sub>3</sub>SnH-Mediated <i>6-Endo/6-Exo-trig</i> Vinyl Radical Cyclization
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2005
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Asymmetric CatalysisDerivativesEngineeringBaylis-hillman AdductsNatural SciencesDiversity-oriented SynthesisPhenyl Homopropargyl DerivativesTrisubstituted TetrahydropyransOrganic ChemistrySynthetic ChemistryStereoselective SynthesisChemistry6-Exo-trig CyclizationBaylis-hillman DerivativesEnantioselective SynthesisBiomolecular Engineering
The stereoselective 6-endo- and 6-exo-trig cyclization of propargyl and phenyl homopropargyl derivatives of Baylis-Hillman adducts by the use of n-Bu3SnH-mediated vinyl radical cyclization afforded poly-substituted functionalized tetrahydropyrans in good yield.