An Efficient Synthesis of Functionalized 6,10-Dioxo-6,10-dihydro-5H-pyrido[1,2-a]quinoxalines and 6,10-Dioxo-6,10-dihydropyrido[2,1-c][1,4]benzoxazines

Abstract

An efficient synthesis of alkyl 8-hydroxy-6,10-di­oxo-6,10-dihydro-5H-pyrido[1,2-a]quinoxaline-7-carboxylates and alkyl 8-hydroxy-6,10-dioxo-6,10-dihydropyrido[2,1-c][1,4]benzoxa­zine-7-carboxylates is described. This involves the reaction between malonyl dichloride and alkyl 2-[3,4-dihydro-3-oxo­quinoxaline 2(1H)-ylidene]acetates or alkyl 2-(2-oxo-2H-benzo[b][1,4]oxazin-3(4H)-ylidene)acetates in CH2Cl2 at room temperature.