Enantio- and Diastereoselective Tandem Zn-Promoted Brook Rearrangement/Ene−Allene Carbocyclization Reaction

Abstract

The zinc-catalyzed addition of various alkynes to acylsilanes followed by a Zn-Brook rearrangement and either the Zn-ene-allene or Zn-yne-allene cyclization led to the enantio- and diastereoselective formation of carbocycles in a single-pot operation.