Simple Ultrasound-Assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-one and 3,4-Dihydropyrimidine-2(1H)-thione-Fused Steroidal Derivatives by a Three-Component Reaction

Abstract

Compounds containing fused 3,4-dihydropyrimidin-2(1<i>H</i>)-one or 3,4-dihydropyrimidine-2(1<i>H</i>)-thione moieties were prepared by three-component reactions of a steroidal or nonsteroidal ketone, an alkyl or aryl aldehyde, and urea or thiourea in the presence of sodium ethoxide. The products were isolated in good yields after short reaction times under mild conditions.