Heterocycles · 2008 · 27 citations · 5 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisOrganometallic SynthesisThiazole Chemistry
An efficient one-pot three component method was developed for the synthesis of highly substituted 2-iminothizolines by the reaction of isothiocyanates, primary amines and α-bromoketones in ambient temperature.The reaction produced the desired products in a completely regioselective manner in excellent yields (78-94%).
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