Asymmetric Synthesis of Activated α-Amino Esters via Chromium Carbene Complex Photochemistry

Abstract

Optically active chromium aminocarbene complexes were α-alkylated and then photolyzed in the presence of 2,4,5-trichlorophenol to produce a number of optically active activated α-amino esters. These underwent coupling with amino acid esters or a soluble PEG-supported dipeptide to introduce the chromium−carbene-complex-derived amino acid residue into the peptide.