One‐Pot Synthesis and Characterization of Some New Types of 5,5′‐Disubstituted Bis(imidazolidine‐2,4‐diones)

Abstract

The synthesis and structural elucidation of some novel 5,5′‐disubstituted spiro and nonspiro‐bis‐hydantoins are reported. The Bucherer Burge's method has been modified for the preparation of some 5,5′‐substituted bis(imidazolidine‐2,4‐dione) derivatives starting with diketones ( 1–5 ) and dialdehydes ( 6 , 7 ). In some cases, diastereoisomeric mixtures of compounds were obtained. The resulting bis‐hydantoins ( 8–11 , 13 , 14 ) have not to our knowledge been previously reported in the literature.