Rumphellolide H, a New Natural Caryophyllane from the Gorgonian Rumphella antipathies

Abstract

A new natural caryophyllane-type sesquiterpenoid, rumphellolide H (1), which possesses a tetrahydropyran moiety in structure, was isolated from the gorgonian coral Rumphella antipathies.The structure of 1 was established by spectral data analysis and this metabolite showed moderate inhibitory effects on elastase release by human neutrophils.