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The Mannich Reaction Between Aromatic Ketones, Aromatic Aldehydes and Aromatic Amines
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1991
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Cross-coupling ReactionAromatic AldehydesEngineeringBiochemistryAcid-catalyzed Mannich ReactionNatural SciencesAromatic AminesOrganic ChemistryCatalysisHigh YieldChemistryStereoselective SynthesisAsymmetric CatalysisChemical KineticsSynthetic ChemistryEnantioselective Synthesis
The acid-catalyzed Mannich reaction of acetophenones with benzaldehyde derivatives and aromatic amines gives 1,3-diaryl-3-(arylamino)propanones in high yield.