Side‐chain chlorination of methylquinolines

Abstract

Abstract Methylquinolines 1–4 were chlorinated by heating with phosphorus pentachloride in chlorobenzenes to side‐chain halogen derivatives 5–14 . Methyl groups of compounds 1–4 can be chlorinated to chloromethyl, dichloromethyl or trichloromethyl groups depending on their positions and the reaction conditions.