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Synthesis of 5-Arylated Indoles via Palladium-catalyzed Cross-coupling Reaction of 5-Indolylboronic Acid with Aryl and Heteroaryl Halides
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1992
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EngineeringCross-coupling Reaction 01Organic ChemistryChemistry5-Arylated IndolesOrganometallic CatalysisStereoselective SynthesisGood Yields.5-arylated IndolesCross-coupling ReactionDiversity-oriented SynthesisVarious ArylPalladium-catalyzed Cross-coupling ReactionCatalysisPharmacologyAsymmetric CatalysisEnantioselective SynthesisNatural Sciences5-Indolylboronic AcidSynthetic Chemistry
Palladium(0)-catalyzed cross-coupling reaction 01 5indolylboronic acid with various aryl and heteroaryl halides results in regioselective formation of 5-arylated indoles in good yields.5-Arylated indoles are important intermediates in our strategy t o synthesize various agonists and antagonists of the central nervous system neurotransmitter serotonin (5-hyroxytryptamine, 5HT).