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Palladium-Catalyzed Novel Cycloisomerization: An Unprecedented Domino Oxidative Cyclization towards Substituted Carbocycles

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2005

Year

Abstract

Efficient Pd-catalyzed cyclization of homoallylated β-bromo-vinylalcohols via a domino process to carbocycle derivatives in presence of different bases is reported. An unexpected and novel palladium-mediated Heck-type intramolecular oxidative ­cyclization of 1-bromohexa-1-ene-5-yn-3-ol derivatives is also ­described.