A Phosphine-Catalyzed [3+6] Annulation Reaction of Modified Allylic Compounds and Tropone

Abstract

A novel phosphine-catalyzed reaction of modified allylic compounds, including acetates, bromides, chlorides, or tert-butyl carbonates derived from the Morita-Baylis-Hillman (MBH) reaction with tropone to yield [3+6] annulation products in excellent yields was developed. It offers a simple and convenient method for constructing bridged nine-membered carbocycles.