1-Aminoalkanephosphonates. Part II. A Facile Conversion of 1-Aminoalkanephosphonic Acids into 0,0-Diethyl 1-aminoalkanephosphonates

Abstract

1-(N-Trifluoroacetylamino)alkanephosphonate 0,0-diethyl esters 2 C, obtained from parent 1-aminoalkanephosphonic acids 1, have been selectively deprotected on the amino function affording 0,0-diethyl 1-aminoalkanephosphonates 3. Protonation constants of all amino esters 3 synthesized have been determined by potentiometric titration.