SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF NOVEL AZOLYL, AZINYL, PYRANYL, CHROMONYL AND AZEPINYL PHOSPHONATES

Abstract

A facile synthetic methodology of novel azolyl, azinyl and azepinyl phosphonates as cyclic α-aminophosphonates was described.Chromonyl α-aminophosphonates, γ-pyranyl and γ-pyridinyl phosphonates were also prepared.The methodology depends on reaction of 6-methyl-3-formylchromone, nitrogen and carbon nucleophiles in the presence of diethyl phosphite in one-pot three-components under solvent-free conditions.The products were evaluated for their antimicrobial activities and antioxidant properties.