Biosynthetic Capacities of Actinomysetes. No.27. Endophenazines A-D, New Phenazine Antibiotics from the Athropod Associated Endosymbiont Streptomyces anulatus. II. Structure Elucidation.

Abstract

A detailed screening of the secondary metabolite pattern produced by different athropod associated strains of the species Streptomyces anulatus resulted in the isolation and structure elucidation of the endophenazines A-D (2, 4-6). The structures were assigned by spectroscopic methods and chemical transformations. 4 represents a chromophoric system based on a phenazin-7-one, 5 and 6 are new 5,10-dihydrophenazine derivatives.