Publication | Closed Access
HIV-1 Protease Inhibitors Based on Acyclic Carbohydrates
44
Citations
26
References
1998
Year
Medicinal ChemistryHiv-1 ProteaseBioorganic ChemistryBiochemistryMedicineNatural SciencesGlycobiologyAntiviral Drug DevelopmentAntiviral TherapyHiv-1 Protease InhibitorsHivAntiviral DrugPharmacologyAntiviral CompoundCarbohydrate-protein InteractionDrug DiscoveryVitro Activity
A series of acyclic C2-symmetric HIV protease inhibitors readily accessible from d-mannitol have been developed. Several of the compounds synthesized showed significant in vitro activity against HIV-1 protease.
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