Preparation of 2,5-Disubstituted Furans from Terminal Ynones and Aldehydes with CrCl2, Me3SiCl, and H2O - Concepedia

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Preparation of 2,5-Disubstituted Furans from Terminal Ynones and Aldehydes with CrCl2, Me3SiCl, and H2O

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References

2001

Year

Kazuhiko Takai, Ryotaro Morita, Shuji Sakamoto

Combinatorial ChemistryEngineeringβ-Acetylenic KetonesExcellent YieldsOrganic ChemistryTerminal YnonesChemistryNatural Product SynthesisEnantioselective SynthesisBiomolecular Engineering2,5-Disubstituted Furans

Abstract

Treatment of α,β-acetylenic ketones with chromium(II) in the presence of aldehydes, Me3SiCl and water in THF gives 2,5-disubstituted furans in good to excellent yields.