Daphnezomines A and B, Novel Alkaloids with an Aza-adamantane Core from <i>Daphniphyllum </i><i>h</i><i>umile</i>

Abstract

Two novel alkaloids with a unique aza-adamantane core, daphnezomines A (1) and B (2), have been isolated from the leaves of Daphniphyllum humile, and the structures including relative stereochemistry were elucidated on the basis of spectroscopic data and chemical means. The absolute configuration of 2 was established by X-ray crystallographic analysis.