CO-Trapping Reaction under Thermolysis of Alkoxyamines: Application to the Synthesis of 3,4-Cyclopenta-1-tetralones

Abstract

[reaction: see text] An efficient one-pot sequence comprising a PRE-mediated radical 5-exo-cyclization, a radical carbonylation, a nitroxide trapping reaction, and a subsequent acid-catalyzed Friedel-Craft-type acylation provides a new entry into 3,4-cyclopenta-1-tetralones. Eight examples are presented.