[2,2]Paracyclophane-Based<i>N</i>,<i>O</i>-Ligands in Alkenylzinc Additions to Aldehydes

Abstract

[reaction: see text] The application of planar and central chiral [2,2]paracyclophane-based N,O-ligands in asymmetric alkenylzinc additions to various aldehydes is described, which gives rise to very high ee's especially for difficult substrates. A fine-tuning of the alkenylzinc species by employing different transmetalation reagents is reported, allowing control of the steric bulk of the alkenylzinc species and thus the selectivity of the catalysis.