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A Simple Procedure for the Synthesis of 4-Aza-podophyllotoxin Derivatives in Water under Microwave Irradiation Conditions
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2006
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Chemical EngineeringBioorganic ChemistryEngineeringPhotochemistryNatural SciencesGreen ChemistrySustainable SynthesisOrganic ChemistrySynthetic ChemistryChemistryNew ProtocolHeterocycle ChemistrySimple ProcedureSynthesis MethodMicrowave SynthesisMicrowave Irradiation Conditions4-Aza-podophyllotoxin Derivatives
4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of higher yield, lower cost, reduced environmental impact, and convenient procedure.