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First Enantiospecific Synthesis of Antileishmanial 12-Deoxyroyleanone from Abietic Acid
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2004
Year
Medicinal ChemistryBiosynthesisBioorganic ChemistryEnantioselective SynthesisBiochemistryPharmaceutical ChemistryNatural SciencesAbietic AcidMedicineAntiparasitic AgentPharmacologyAppreciable Antileishmanial ActivityAbietane DiterpenoidDrug DiscoveryNatural Product Synthesis
12-Deoxyroyleanone (1), an abietane diterpenoid with appreciable antileishmanial activity, has been efficiently synthesized from abietic acid (10; 11 steps for a 25% overall yield).