Total Synthesis of Macrocyclic Antibiotic, Micrococcin P1

Abstract

Total synthesis of a macrocyclic antibiotic, micrococcin P I (1).constructed from four segments called Fragments A, B, C, and D, was achieved.The synthesis of a central 2,3,6-trithiazole-substituted pyridine moiety [Fragment A with C (A-C)], followed by coupling with Fragments B and D synthesized independently gave the protected Fragment A-B-C-D.Final deprotection of all the protecting groups and cyclization gave synthetic 1.Micrococcin P I (11,' isolated from the culture of Bacillus pumilus, is a unique macrocyclic antibiotic.So 2 far, although many similar antibiotics have been isolated from various kinds of strains, the synthesis of 3.4