Concepedia

One-pot Mannich-Type Reaction In Water: HBF<sub>4</sub> Catalyzed Condensation of Aldehydes, Amines, and Silyl Enolates for the Synthesis of β-Amino Carbonyl Compounds

Takahiko Akiyama, Jun Takaya, Hirotaka Kagoshima

Synlett · 1999 · 67 citations · 0 references

Concepts

Natural SciencesChemistryCatalysisOrganic ChemistryAmino Acid ChemistryOrganic SynthesisSurfactantsAldol CondensationAldol ReactionAmino AcidsAmino Carbonyl Reaction

Abstract

HBF4 catalyzed Mannich-type reactions of aldehydes, amines, and silyl enolates took place smoothly in water in the presence of a surfactant to afford β-amino carbonyl compounds in high yields.