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Copper-Catalyzed N-Arylation of Amines/Amides in Poly(ethylene glycol) as Recyclable Solvent Medium
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2006
Year
Ethylene GlycolEngineeringRecyclable Solvent MediumCopper-catalyzed N-arylationOrganic ChemistryChemistryChemical EngineeringCatalyst RecyclabilityPolymer ChemistryCross-coupling ReactionBuchwald N-arylationSolvent MediumCatalysisAsymmetric CatalysisCatalytic SynthesisBiomolecular EngineeringMolecular CatalysisPolymer ReactionPolymer Synthesis
The Buchwald N-arylation of amines and amides is achieved efficiently in PEG (400 Daltons) as solvent medium. The solvent and catalyst recyclability is studied. Interestingly amides underwent N-arylation with better yields.