Total Synthesis of Antibiotic, Micrococcin P, from 2,3,6-Polythiazolesubstituted Pyridine Skeleton [Fragment A-C]

Abstract

Abstract Total synthesis of an antibiotic, micrococcin P, was first accomplished by the coupling of a 2,3,6-polythiazole-substituted pyridine skeleton [Fragment A-C] with the independently synthesized Fragments B and D, and then deprotection with trifluoroacetic acid and final intramolecular cyclization using BOP as condensing agent.