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Nanocrystalline Magnesium Oxide Stabilized Palladium(0): An Efficient Heterogeneous Catalyst for Heck and Sonogashira Coupling of Aryl Halides
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2006
Year
Materials ScienceAryl HalidesCross-coupling ReactionEngineeringSubstituted OlefinsEfficient Heterogeneous CatalystSonogashira CouplingNanocrystalline MagnesiumOrganometallic CatalysisCatalysisSingle-atom CatalystChemistrySubstituted AlkynesCatalyst PreparationCatalytic Synthesis
Nanocrystalline magnesium oxide supported palladium(0) catalyst [NAP-Mg-Pd(0)], prepared by the counter-ion stabilization of PdCl4 2- followed by reduction with hydrazine hydrate, was effectively used in the Heck olefination of haloarenes (chloro, bromo, and iodo) to afford good to excellent yields of substituted olefins. This ligand-free heterogeneous NAP-Mg-Pd(0) catalyst was quantitatively recovered from the reaction by a simple filtration and reused for a number of cycles with almost no loss of activity. Moreover, NAP-Mg-Pd(0) efficiently catalyzed the Sonogashira coupling of haloarenes with terminal alkynes without any copper co-catalyst under milder conditions to afford excellent yields of substituted alkynes.