Synthesis and Antimicrobial Evaluation of Novel Pyrazolo[1,5-a]pyrimidine, Triazolo[1,5-a]pyrimidine and Pyrimido[1,2-a]benzimidazole Derivatives

Abstract

The applicability and synthetic potency of E-1-(1-methylbenzimidazol-2-yl)-3-N,N-dimethylaminoprop-2-enone towards some nitrogen nucleophiles was investigated as a convenient route for the synthesis of some novel aminopyrimidine, pyrazolo[1,5-a]pyrimidine, triazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole, and pyrido[2,3-d]pyrimidine derivatives.Some of the newly synthesized compounds were tested in vitro for their antibacterial and antifungal activities, and showed promising results.