TBAF-Assisted Copper-Catalyzed <i>N</i>-Arylation and Benzylation of Benzazoles with Aryl and Benzyl Halides under the Ligand/Base/ Solvent-Free Conditions

Abstract

TBAF-assisted N-arylation and benzylation of benzazoles such as 1H-benzimidazole, 1H-indole, and 1H-benzotriazole with aryl and benzyl halides have been demonstrated under the ligand/base/solvent-free conditions. In the presence of CuBr2 and TBAF (n-Bu4NF), the azoles underwent N-arylation and benzylation with aryl and benzyl halides smoothly in moderate to good yields. It is noteworthy that the reaction is conducted under the ligand/base/solvent-free conditions.