Synthesis and biological testing of 3‐phenyloctahydro‐pyrimido[1,2‐<i>a</i>]‐<i>s</i>‐triazine derivatives

Abstract

Abstract A series of 46 3‐phenyloctahydropyrimido[1,2‐ a ]‐ s –triazine derivatives were synthesized. This synthesis was performed via iminodimethylation of dialkylated 2‐aminopyrimidinedione synthons by substituted primary arylamines. In vitro pharmacological evaluation of these compounds is reported. One of them exhibited antifungal activity against Microsporum canis (10 −6 50 10 −5 mol/L), and another showed affinity for serotoninergic 5‐HT 1A and 5‐HT 2b receptors (10 −8 50 10 −7 mol/L).