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Direct Cobalt-Catalyzed Cross-Coupling Between Aryl and Alkyl Halides
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2009
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Asymmetric CatalysisHalogenationChemical EngineeringCross-coupling ReactionEngineeringNovel OrganocatalystsAlkyl HalidesOrganic ChemistrySimple Cross-coupling ReactionOrganometallic CatalysisCatalysisChemistryHigh SelectivityHigh Sustainability
An operationally simple cross-coupling reaction between aryl halides and alkyl halides with high selectivity has been developed. The underlying domino process utilizes CoCl2/Me4-DACH as a catalyst system. The methodology exhibits high sustainability as it obviates the need for the pre-formation and handling of stoichiometric amounts of hazardous Grignard compounds.