Studies on 1,2,3-triazole derivatives as in vitro inhibitors of prostaglandin synthesis.

Abstract

This paper reports some new structural modifications (branching and lengthening of alkanoic substituent, increase of heterocycle-carboxylate distance) on 1,2,3-triazole derivative 1, a potent in vitro inhibitor of prostaglandin synthesis, and their influence on enzyme activity. Regarding the structural relationship between 1 and Dazoxiben, a selective thromboxane-synthetase inhibitor, the preparation and activity of some Dazoxiben analogs bearing different heterocycles, are also described.