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Enantioselective Hydrogenation of Functionalized Ketones. Synthesis and Application of New Chiral Aminophosphine-Phosphinite Ligands
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1998
Year
Chemical EngineeringEnantioselective SynthesisEngineeringBiochemistryNatural SciencesDihydro-4,4-dimethyl-2,3-furandione 8Organic ChemistryCatalysisChiral New Aminophosphine-phosphinitesChemistryStereoselective SynthesisAsymmetric CatalysisSynthetic ChemistryEnantioselective HydrogenationFunctionalized Ketones
The chiral new aminophosphine-phosphinites (AMPP's 1-7) have been synthesized and applied successfully in the enantioselective hydrogenation of dihydro-4,4-dimethyl-2,3-furandione 8, N-benzylbenzoylformamide 9, and ethylpyruvate 10 providing the hydroxy products in up to 97, 95, and 80% ee, respectively.