Publication | Closed Access
Synthesis of Diospyrin, a Potential Agent Against Leishmaniasis and Related Parasitic Protozoan Diseases
28
Citations
17
References
2000
Year
First SynthesisMedicinal ChemistryDerivative (Chemistry)BiochemistryAntiparasitic AgentNatural SciencesDrug DiscoveryDiversity-oriented SynthesisMedicineParasitic ProtozoaOrganic ChemistryKey ReactionPharmacology7-Methyljuglone UnitsVisceral LeishmaniasisSynthetic ChemistryBiomolecular Engineering
The first synthesis of diospyrin [2,6′-bis(5-hydroxy-7-methyl-1,4-naphthoquinone), 1] was achieved by employing Suzuki coupling between 5 and 14 as the key reaction to connect the two 7-methyljuglone units.
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