Microwave-Promoted Efficient Synthesis of Benzo[h]quinolines by Solvent-Free Three-Component Imino-Diels-Alder Reaction under One-Pot Conditions

Abstract

An one-pot, solvent-free imino Diels–Alder reaction has been developed under microwave conditions using 1-naphthylamine, aldehydes, and electron-deficient terminal alkynes in the presence of a catalytic amount of In(OTf)₃ for construction of benzo[<i>h</i>]quinoline derivatives in short reaction times. The method is clean and operationally simple.