Concepedia

Synthesis and evaluation of antifungal and antibacterial activity of ethyl 3,5-diarylisoxazole-4-carboxylates

K. Ajay Kumar, K. M. Lokanatha, K. B. Umesha

Journal of Chemical Research · 2001 · 31 citations · 8 references

DOI

Concepts

Abstract

Nitrile oxides generated in situ by the oxidative dehydrogenation of aldoximes (2) react with α-cyanocinnamate esters (1) to afford ethyl 3,5-diarylisoxazole-4-carboxylates (4) in good yield. The esters (4) were tested for their antimicrobial activity.

References

8

1,3‐Dipolar Cycloadditions. Past and Future

Rolf Huisgen · Angewandte Chemie International Edition in English · 1963 · 2.8K citations

, , +10

INTERPRETATION OF MASS SPECTRA

Analytical Chemistry · 1991 · 1.9K citations

, , +12

The isoxazoline route to the molecules of nature

Alan P. Kozikowski · Accounts of Chemical Research · 1984 · 535 citations

, , +6

A New Method for the Generation of Nitrile Oxides and Its Application to the Synthesis of 2-Isoxazolines

K. M. Lokanatha · Synthesis · 1989 · 122 citations

, , +7

Rapid screening of the antimicrobial activity of extracts and natural products.

Satish Chand, Isaac Lusunzi, D.A. Veal et al. · The Journal of Antibiotics · 1994 · 110 citations · Full text

, , +13