Assessing the Effect of Various Blood Glucose Levels on ¹⁸F-FDG Activity in the Brain, Liver, and Blood Pool

Abstract

Studies have extensively analyzed the effect of hyperglycemia on ¹⁸F-FDG uptake in normal tissues and tumors. In this study, we measured SUV in the brain, liver, and blood pool in normoglycemia, hyperglycemia, and hypoglycemia to understand the effect of blood glucose on ¹⁸F-FDG uptake and to develop a formula to correct SUV. <b>Methods:</b> Whole-body ¹⁸F-FDG PET/CT images of adults were selected for analysis. Brain SUV_max, blood-pool SUV_mean, and liver SUV_mean were measured at blood glucose ranges of 61-70, 71-80, 81-90, 91-100, 101-110, 111-120, 121-130, 131-140, 141-150, 151-160, 161-170, 171-180, 181-190, 191-200, and 201 mg/dL and above. At each blood glucose range, 10 PET images were analyzed (total, 150). The mean (±SD) SUV of the brain, liver, and blood pool at each blood glucose range was calculated, and blood glucose and SUV curves were generated. Because brain and tumors show a high expression of glucose transporters 1 and 3, we generated an SUV correction formula based on percentage reduction in brain SUV_max with increasing blood glucose level. <b>Results:</b> Mean brain SUV_max gradually decreased with increasing blood glucose level, starting after a level of 110 mg/dL. The approximate percentage reduction in brain SUV_max was 20%, 35%, 50%, 60%, and 65% at blood glucose ranges of 111-120, 121-140, 141-160, 161-200, and 201 mg/dL and above, respectively. In the formula we generated, measured SUV_max is multiplied by a reduction factor of 1.25, 1.5, 2, 2.5, and 2.8 for the blood glucose ranges of 111-120, 121-140, 141-160, 161-200, and 201 mg/dL and above, respectively, to correct SUV. Brain SUV_max did not differ between hypoglycemic and normoglycemic patients (<i>P</i> > 0.05). SUV_mean in the blood pool and liver was lower in hypoglycemic patients (<i>P</i> < 0.05) and did not differ between hyperglycemic (<i>P</i> > 0.05) and normoglycemic patients. <b>Conclusion:</b> Hyperglycemia gradually reduces brain ¹⁸F-FDG uptake, starting after a blood glucose level of 110 mg/dL. Hyperglycemia does not affect ¹⁸F-FDG activity in the liver or blood pool. Hypoglycemia does not seem to affect brain ¹⁸F-FDG uptake but appears to reduce liver and blood-pool activity. The simple formula we generated can be used to correct SUV in hyperglycemic adults in selected cases.