Modification of Chiral Monodentate Phosphine (MOP) Ligands for Palladium-Catalyzed Asymmetric Hydrosilylation of Styrenes

Abstract

Abstract In the palladium-catalyzed asymmetric hydrosilylation of styrene with trichlorosilane, several chiral monophosphine ligands, (R)-2-diarylphosphino-1,1′-binaphthyls (2), were examined for their enantioselectivity. The highest enantioselectivity was observed in the reaction with (R)-2-bis[3,5-bis(trifluoromethyl)phenyl]phosphino-1,1′-binaphthyl (2g), which gave (S)-1-phenylethanol of 98% ee after oxidation of the hydrosilylation product.