Publication | Closed Access
2-Substituted 3-Aryl- and 3-Heteroarylindoles by the Palladium-Catalyzed Reaction of<i>o</i>-Trifluoroacetanilides with Aryl Bromides and Triflates.
57
Citations
0
References
2003
Year
Cross-coupling ReactionEngineeringExcellent YieldNatural SciencesDiversity-oriented Synthesis2-Substituted Indole-3-carboxaldehydesOrganic ChemistryOrganometallic CatalysisCatalysisChemistryHeterocycle ChemistryAryl BromidesAsymmetric CatalysisSynthetic ChemistryPalladium-catalyzed Reaction
The palladium-catalyzed reaction of aryl and heteroaryl bromides and triflates with o-alkynyltrifluoroacetanilides affords 2-substituted 3-aryl- and heteroarylindoles usually in excellent yield. The procedure can be applied to the synthesis of 2-substituted indole-3-carboxaldehydes.