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Novel Synthesis of Functionalized Indolizine Derivatives from Huisgen's Zwitterions and 1-Methylimidazole/Dichloroketene Adduct
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2012
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Pyridine DerivativesDerivative (Chemistry)Moderate Yields1-Methylimidazole/dichloroketene AdductOrganic ChemistryNovel SynthesisChemistryHeterocycle ChemistryPharmacologyFunctionalized IndolizineSynthetic ChemistryReactive Zwitterionic Intermediates
The reactive zwitterionic intermediates, generated from addition of pyridine derivatives to dialkyl acetylenedicarboxylates, react with 1-methylimidazole/dichloroketene adduct to afford functionalized dialkyl 1-(2,2-dichloroacetyl)indolizine-2,3-dicarboxylates in moderate yields.