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Tandem Cyclization of a Bispyridinium Chloride: Facile Synthesis of Substituted Indolizines
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2013
Year
Chemical EngineeringDiversity Oriented SynthesisEngineeringBispyridinium ChlorideNatural SciencesDiversity-oriented SynthesisSubstituted IndolizinesOrganic ChemistryTandem CyclizationBispyridinium SaltsOne-pot Cascade ReactionChemistryHeterocycle ChemistryNatural Product SynthesisSynthetic ChemistryIndolizine Scaffold
Functionalized indolizines were prepared by a one-pot cascade reaction from bispyridinium salts. This mild experimental procedure allowed the isolation of the product in very good yield. Combination of the indolizine derivative with electrophiles confirmed the reactivity of the C<sub>3</sub> ring carbon and allowed the bromination, formylation, hydroxymethylation, and dimerization of the indolizine scaffold.