Domino Reactions - New Concepts in the Synthesis of Indole Alkaloids and Other Polycyclic Indole Derivatives

Abstract

2-Vinylindoles, which are easily accessible via a domino process, are useful synthons for a variety of applications. Subsequent Diels-Alder reactions yield tetrahydrocarbazoles which can be dehydrated to carbazoles such as derivatives of olivacine or elipticine. Cycloadditions with enamine intermediates led to the synthesis of epidasycarpidone.