Journal of Medicinal Chemistry · 1992 · 75 citations · 0 references
Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicineNatural SciencesEther FunctionPharmacological AgentPharmacotherapyNew SeriesNovel Thiazolidine-2,4-dionesDrug DevelopmentInsulin-resistant Ob/ob MousePharmacologyHeterocycle ChemistryPharmaceutical ChemistryDrug Discovery
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.