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A One-Step Approach to 1-(Fluoroalkyl)indolizine Derivatives
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1999
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Medicinal ChemistryDerivative (Chemistry)DerivativesPyridazinium YlidesFacile One-step MethodNatural SciencesFluorous SynthesisOrganic ChemistryOne-step ApproachChemistryIndolizine DerivativesHeterocycle ChemistryPharmacologyChemical DerivativeSynthetic Chemistry
A facile one-step method is presented for the synthesis of 1-(fluoroalkyl)-substituted indolizine derivatives in moderate to good yields by reactions of pyridinium, 4-methylpyridinium, isoquinolinium, and pyridazinium ylides with 2-bromo-3,3,3-trifluoropropene and 1-iodo-2-(polyfluoroalkyl)ethenes, respectively, in the presence of base.