Isolation, Structure Elucidation, and Syntheses of Isoneocryptotanshinone II and Tanshinlactone A from Salvia miltiorrhiza

Abstract

Two new components, isoneocryptotanshinone II (1) and tanshinlactone A (2), were isolated from an EtOH extract of Salvia miltiorrhiza.The structures of 1 and 2 were established by spectroscopic methods and total syntheses.Compound (2) exhibited moderate cytotoxic activities with a CD 50 range of 6.87-8.85µg/mL against the HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma) and OVCAR-3 (ovarian adenocarcinoma) cell lines.