Publication | Closed Access
Zincke's Reaction with Chiral Primary Amines: A Practical Entry to Pyridinium Salts of Interest in Asymmetric Synthesis
58
Citations
0
References
1992
Year
Chemical EngineeringEngineeringHeterocyclicPositions 3Accepted MechanismAsymmetric SynthesisPractical EntryChiral Primary AminesOrganic ChemistrySynthetic ChemistryChemistryHeterocycle ChemistrySynthesis MethodAsymmetric CatalysisPyridinium SaltsEnantioselective Synthesis
The scope of Zincke's synthesis of pyridinium salts using various chiral primary amines and mono- or dialkylpyridines substituted at positions 3, 4 or 5 has been investigated. Salts 6a-f, 9a-i, and 10b,e,h-j were obtained in excellent yields. The results support the accepted mechanism for Zincke's reaction and shows the influence of the solvent on the course of this reaction.