Synlett · 2012 · 55 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryCatalytic MechanismsHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisArene FunctionalizationC - H Bond FunctionalizationC-h ActivationDirected C - H ActivationHeterocycle FunctionalizationQuinoline ChemistryQuinoline SynthesisRegioselectivity
2-Aryl-4-quinazolinones undergo smooth acetoxylation in the presence of 5 mol% Pd(OAc)<sub>2</sub> and a stoichiometric amount of PhI(OAc)<sub>2</sub> via C–H activation to produce the corresponding acetoxy-substituted 4(3<i>H</i>)-quinazolinone derivatives in good yields with high regioselectivity.