<i>C</i> ₂-Symmetric Bioxazolines and Bithiazolines as New Chiral Ligands for Metal Ion Catalyzed Asymmetric Syntheses: Asymmetric Hydrosilylation

Abstract

New chiral C2 -symmetric bioxazolines (4,4′ -disubstituted 4,5,4′ ,5′ -tetrahydro-2,2′ -bioxazoles) and bithiazolines (4,4′ -disubstituted 4,5,4′ ,5′ -tetrahydro-2,2′ -bithiazoles) obtained in a few simple steps from amino acids were found to induce up to 84% enantiomeric excess in the rhodium(I)-catalyzed asymmetric hydrosilylation of acetophenone.