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<i>C</i> <sub>2</sub>-Symmetric Bioxazolines and Bithiazolines as New Chiral Ligands for Metal Ion Catalyzed Asymmetric Syntheses: Asymmetric Hydrosilylation
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1991
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Bioorganic ChemistryAmino AcidsEngineeringAsymmetric HydrosilylationOrganic ChemistryChemistryOrganometallic CatalysisStereoselective Synthesis,5′ -Tetrahydro-2,2′ -BioxazolesBiochemistryDiversity-oriented SynthesisNew Chiral LigandsCatalysisNatural Product SynthesisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringNatural SciencesSynthetic Chemistry
New chiral C2 -symmetric bioxazolines (4,4′ -disubstituted 4,5,4′ ,5′ -tetrahydro-2,2′ -bioxazoles) and bithiazolines (4,4′ -disubstituted 4,5,4′ ,5′ -tetrahydro-2,2′ -bithiazoles) obtained in a few simple steps from amino acids were found to induce up to 84% enantiomeric excess in the rhodium(I)-catalyzed asymmetric hydrosilylation of acetophenone.